Custom Peptides
Cayman Chemical DIhydroartemIsInIc AcId 10mg
A biosynthetic precursor to artemisinin; an intermediate in the synthesis of artemisinin from artemisinic acid
Cayman Chemical ShnzhIsIde methyl ester 10mg
An iridoid glycoside with anti-inflammatory and antinociceptive activities; a GLP-1R agonist; inhibits the release of MPO and elastase from fMLP-activated isolated rat neutrophils at 10 µM; inhibits LPS-induced increases in the release of IL-8 and LTB4 from isolated rat neutrophils at 10 µM; reduces L5/L6 spinal nerve ligation-induced mechanical allodynia in rats (ED50 = 40.4 UG/animal)
Cayman Chemical 4 2 2 3TrImthylcycloPNtyl 10mg
An orthosteric, insurmountable antagonist of the human bitter taste receptors hTAS2R31 and hTAS2R43; prevents the activation of hTAS2R31 by saccharin and acesulfame K in cells (IC50s = 7.9 and 2.4 µM, respectively)
Cayman Chemical trmentIc AcId 10mg
A triterpene with diverse biological activities; reduces hydrogen peroxide-induced increases in iNOS and NOX1, as well as the production of TNF-α, IL-6, and IL-1β in RVSMCs at 12.5, 25, and 50 µM; decreases hydrogen peroxide-induced ROS generation in RVSMCs at 25 and 50 µM; reduces TPA-induced EAr edema in mice (ID50 = 0.03 mg/ear); reduces the number of papillomas formed per mouse in a DMBA-TPA two-stage model of mouse skin carcinogenesis at a topical dose of 1.7 nmol; reduces increases in blood glucose, insulin, and leptin levels, as well as hepatic triglyceride levels, in mice fed a high-fat diet at 60 and 120 mg/kg per day
Cayman Chemical ACTH11-24humnmouser 10mg
A peptide fragment of ACTH and an MC2R antagonist (IC50 = ~1 nM in HeLa cells expressing the mouse receptor); induces corticosterone and aldosterone production in isolated rat zona glomerulosa and zona fasciculata cells, respectively, with minimum effective concentrations of 4 and 3 µM, respectively; inhibits ACTH-induced stretching, yawning, and penile erections in rats at 1.69 UG/animal, i.c.v.
Cayman Chemical TemsIrolImus 10mg
A dihydroxymethyl propionic acid ester of rapamycin with improved solubility that specifically inhibits mTOR signaling with a potency similar to that of rapamycin; demonstrates cytostatic activity in various mouse models of human tumors, including glioblastomas, prostate carcinoma, pancreatic, liver, breast cancers, and medulloblastoma
Cayman Chemical Nutln-3 10mg
An inhibitor of the p53-Mdm2 interaction (IC50 = 0.09 µM); increases p53 levels, induces apoptosis, and reduces cell viability in HCT116, SJSA-1, and RKO cells; reduces tumor volume in SJSA-1, MHM, LNCaP, and 22Rv1 mouse xenograft models at 200 mg/kg
Cayman Chemical 4-octynyl Itaconate 10mg
An alkyne derivative of 4-octyl itaconate; can be used for click chemistry applications
Cayman Chemical ZFRAMCtrIfluoroACTAte sa 10mg
A fluorogenic substrate for cathepsin L; AMC is released upon enzymatic cleavage by cathepsin L and its fluorescence can be used to quantify cathepsin L activity; ex/em = 340-360/440-460 nm, respectively
Cayman Chemical ZLN005hydrochlorIde 10mg
A small molecule that stimulates the expression of PGC-1α and downstream genes in skeletal muscle cells, improving glucose utilization and fatty acid oxidation at a concentration of 20 μM; 15 mg/kg/day administered to diabetic db/db mice improved glucose tolerance, pyruvate tolerance, and insulin sensitivity
Cayman Chemical RPalmItoyl 1methyl Ethno 10mg
A synthetic analog of PEA which incorporates an (R)-methyl group vicinal to the alcohol on the ethanolamine moiety, which may protect the molecule from enzymatic hydrolysis, leading to prolonged duration of action and enhanced potency in vivo; expected to show enhancement of the inhibitory activity of PEA on mast cells and other cells known to express the CB2 receptor
Cayman Chemical 4ndrosten11ol3 17dIon 10mg
A non-androgenic steroid; metabolized to various androgenic 5α-reduced C19 steroids in LNCaP cells